領(lǐng)學(xué)術(shù)科研之先，創(chuàng)食品科技之新
—— 中國食品雜志社
Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide
receptor (CGRP)whenassociates withhumanreceptor activity-modifying protein-1 (HRAMP1).CGRP
is believed to be involved in triggering of migraine. Many strategies were employed to design antimigraine
drug using various CGRP antagonist/ligands but most of them have failed due to their inability to
reach the target “CGRP receptor” as they get metabolized before conferring their pharmacological action
and exhibit toxic effect to the liver. The present study, evaluated the binding of 13 phyto-chemical compounds
of “Abrus precatorius” identified throughGCMSanalysis against the protein CGRP using “Discovery
Studio software”. The molecular docking study and ADME/T properties prediction were performed with
the compounds using C-DOCKER module. The results showed that five lead compounds of A. precatorius
may act as good inhibitors for migraine headache and the compounds can be re-designed and synthesized
for better antimigraine activity.
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