領(lǐng)學(xué)術(shù)科研之先，創(chuàng)食品科技之新
—— 中國食品雜志社
The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of liver. In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.
電話: 010-87293157
地址: 北京市豐臺區(qū)洋橋70號
版權(quán)所有 @ 2023 中國食品雜志社 京公網(wǎng)安備11010602060050號 京ICP備14033398號-2
