領(lǐng)學(xué)術(shù)科研之先，創(chuàng)食品科技之新
—— 中國食品雜志社
The gut microbiota and it’s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia, which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota and it’s metabolites directly, the rebalanced intestinal flora mediated by PP04 could facilitate the secretion of short chain fatty acids to control body weight gain, PP04 intervention also changed bile acid (BA) profiles and enhanced the ileal concentrations of antagonists including tauro-α/β-muricholic acid sodium salt and ursodeoxycholic acid to inhibit intestinal farnesoid X receptor/fibroblast growth factor 15 (FXR/FGF15) signaling coupled with the activation of hepatic FXR/small heterodimer partners signaling, which accelerated the hepatic BA de novo synthesis and excretion with feces to eliminate HFD caused hyperlipemia effectively. This study provided important evidence regarding PP04 as dietary supplement to relieve hyperlipidemia by influencing BA enterohepatic circulation.
電話: 010-87293157
地址: 北京市豐臺區(qū)洋橋70號
版權(quán)所有 @ 2023 中國食品雜志社 京公網(wǎng)安備11010602060050號 京ICP備14033398號-2
